Recently, He et al1 published an article in Infection and Drug Resistance entitled “Multifunctional Irrigation-Assisted Vacuum Drainage versus Traditional Drainage in the Treatment of Odontogenic Deep Fascial Infection: A Retrospective Cohort Study”. The results mentioned in the original article1 are inaccurate, because the authors did not take into account hot alkaline solutions of hydrogen peroxide, which allowed the authors to downplay the effectiveness of drug therapy for purulent wounds. In essence, the article by He et al1 is dedicated to proving the advantages of the Modified Multifunctional Vacuum Drainage with Irrigation Support (MIVD) developed by them in the treatment of patients with odontogenic infection of the deep fascial space in the head and neck region. They noted that the current traditional drainage method is passive and dependent on gravity. However, the authors did not investigate the possibility of a geyser effect of hot alkaline solutions of hydrogen peroxide, which easily and inexpensively allow thick pus to dissolve and be removed during drainage, regardless of severity. . The authors take antibiotics into account, but do not take into account antiseptic solutions, nor the physicochemical properties of drugs such as temperature, concentration, osmotic, acid (alkaline) and gas activity.
Then there are questions: 1) Is it true that a hydrogen peroxide solution is not used for drainage? 2) How does the temperature of the hydrogen peroxide solution affect the efficiency of traditional drainage? 3) Can hydrogen peroxide solutions be alkaline and how does it affect the effectiveness of traditional technology to wash purulent wounds? 4) Is it possible to additionally enrich hydrogen peroxide solutions with gas and how does this affect the effectiveness of traditional technology for washing purulent wounds?
First, under the conditions of purulent surgery departments, solutions of chemotherapeutic and antiseptic agents are widely used for drainage of purulent wounds. Among antiseptics, the most common use is for 3-6% hydrogen peroxide solutions.
Second, heating the hydrogen peroxide solution to + 37– + 45 ° C increases its effect on thick pus and increases the efficiency of drainage.2.3
Third, hydrogen peroxide solutions can be alkaline. To do this, sodium bicarbonate is added to the solutions, which gives a pH of 8.4. The effect of hydrogen peroxide solution on pus at pH 8.4 is higher than at pH 7.0 and lower than this value. So, an alkaline solution of hydrogen peroxide increases the effectiveness of traditional technology for washing purulent wounds.4
And, finally, the hot alkaline solutions of hydrogen peroxide can be further enriched in gas, for example in gaseous oxygen. To do this, gases are introduced into solutions under excessive pressure. Enriching a hot alkaline solution of hydrogen peroxide with gaseous oxygen turns it into a powerful whitening cleanser, which is recommended as the most powerful and effective hygiene product that has no effect. ‘equal today.4.5
Therefore, more research is needed to prove the undeniable benefits of MIVD.
The author does not report any conflict of interest related to this communication.
1. He D, Qian Y, Zhou L, Qi H, Liu Y. Multifunctional vacuum assisted drainage versus traditional drainage in the treatment of odontogenic deep fascia infection: a retrospective cohort study. Infect drug resistance. 2021; 14: 3571-3580. doi: 10.2147 / IDR.S326300
2. Urakov A, Urakova N, Reshetnikov A, Kopylov M, Chernova L. Solvents from pus – drugs with aggressive physicochemical action. J Phys Conf Ser. 2017; 790 (1): 12033. doi: 10.1088 / 1742-6596 / 790/1/01203
3. Urakov AL. Pus solvents as new drugs with unique physical and chemical properties. Rev Clin Pharmacol Drug Ther. 2019; 17 (4): 89-95. doi: 10.17816 / RCF17489-95
4. Urakov A, Urakova N, Reshetnikov A. Alkaline oxygen dental cleaners from dental plaque, food debris, blood stains and pus: a narrative review of the history of inventions. J Int Soc Prev Community Dent. 2019; 9 (5): 427-433. doi: 10.4103 / jispcd.JISPCD_296_19
5. Urakov AL. Creation of “necessary” mixtures of baking soda, hydrogen peroxide and hot water as a modernization strategy for ceramic bleach cleaners. Compos-mater based on silicate Epitoanyag J. 2020; 72 (1): 30-35. doi: 10.14382 / epitoanyag-jsbcm.200.6